
CITYSunTimes Web Exclusives October 2009
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HEALTH & WELLNESS
WHAT YOU DON’T KNOW, CAN’T HELP YOU

Fat Soluble Vitamins & Cardiovascular Health
By Steven P. Timmons
Within the last decade, the idea of raising the recommended levels of vitamin D3 supplementation has grown in popularity to the point where most health professionals agree that the old recommendation of 400 IU per day is inadequate. While mainstream medicine is now often recommending 1,000 to 2,000 IU of vitamin D3, many scientists and doctors are recommending levels of 4,000 to 10,000 IU per day as a more natural and beneficial level, not only for preventing osteoporosis, but to attempt to prevent many forms of cancer and to minimize the likelihood of peripheral arterial disease, which eventually leads to atherosclerosis and arteriosclerosis. In fact, 10,000 IU approximates the amount that would be made naturally from the normal amounts of sun exposure expected in people who wear less clothing in tropical regions.
Vitamin D3 has been shown to have many beneficial effects on decreasing vascular inflammation, and a deficiency in vitamin D has been linked to increases in coronary artery disease, hypertension, atherosclerosis and many other forms of cardiovascular disease (CVD). Supplementation with vitamin D has been shown to decrease C reactive protein, Tumor Necrosis factor alpha, natriuretic peptides, parathyroid hormone and other markers of CVD.
For several years, we have recommended higher doses of vitamin D3 at our pharmacy and also suggested the use of vitamin K2, another fat soluble vitamin, as a beneficial vitamin supplement for cardiovascular health, mainly because of studies that showed that vitamin K2 was essential for the action of Gla proteins such as osteocalcin and the matrix-Gla proteins, which prevent the calcification of soft tissues throughout the body, especially the blood vessels and the heart muscle (myocardium).
The idea that vitamin K can actually support vitamin D synergistically in its role as a cardiovascular vitamin has been recently heralded by scientists such as C. Masterjohn and by Lara Pizzorno in her recent review articles for Longevity Medicine Review.
The main reason that some medical experts do not recommend higher doses of Vitamin D3 supplementation is because doses above 50,000 IU per day may increase the danger of soft tissue calcification. For those who are worried about too much vitamin D, it is interesting that vitamin K2 appears to prevent the possibility of such calcification from occurring. Vitamin K2, through its effect on Gla proteins, helps to ensure the elasticity of the arterial walls, helps to decrease calcification of the coronary arteries and may even help prevent varicosities in veins by helping to carboxylate the matrix-Gla proteins in the body. Other forms of vitamin K do not have the same effect.
Vitamin A is another fat soluble vitamin. Vitamin A, among other benefits, helps to control the interaction of vitamin D and vitamin K, preventing vitamin D from depleting vitamin K, and further stabilizing the balance of calcification in arterial walls.
I can only hope that by supplementing all of the fat soluble vitamins at the appropriate levels the focus in cardiovascular medicine will shift to preventing disease, allowing us to avoid the side effects of more toxic symptomatic therapies.
HEALTH & WELLNESS Web Exclusive | CITYSunTimes October 2009

A recent report published in The Journal of Nutrition shows soy supports a healthy heart and bones. The new research detailed in the report was presented at the eighth International Soy Symposium.